BPN-15606 is a highly potent, orally active gamma-secretase modulator (GSM), attenuates the production of Abeta42 and Abeta40 by SHSY5Y neuroblastoma cells with IC50 values of 7 nM and 17nM, respectively. BPN-15606 lowers Abeta42 and Abeta40 levels in the central nervous system of rats and mice. BPN-15606 has acceptable PK/PD properties, including bioavailability, half-life, and clearance[1].
Molecular Weight:
418.47
Purity:
99.96
CAS Number:
[1914989-49-3]
Formula:
C23H23FN6O
Target:
gamma-secretase
Application Notes:
MCE Product type: Reference compound
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