CBR-096-4 is a derivative of Itraconazole (HY-17514). CBR-096-4 is an orally active antifibrotic agent with no CYP3A4 inhibitory activity. CBR-096-4 inhibits the formation of matrix-secreting activated myofibroblasts (MFBs) from multiple tissue types. CBR-096-4 inhibits Hedgehog reporter activity (GLI-LUC), VEGF-dependent growth, and alphaSMA-LUC reporter activity. CBR-096-4 can be used for research of fibrosis[1].
Molecular Weight:
636.74
CAS Number:
[1776931-05-5]
Formula:
C35H40N8O4
Target:
Hedgehog
Application Notes:
MCE Product type: Reference compound1
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