HJC0123 is a STAT3 inhibitor. HJC0123 inhibits the proliferation of hepatic stellate cells and induces cell cycle arrest and apoptosis. HJC0123 reduces the phosphorylation, nuclear translocation and transcriptional activities of STAT3, increases the production of IL-6, inhibits the phosphorylation of Smad2/3 and down-regulates SOCS3. HJC0123 can be used in the study of liver fibrosis[1].
Molecular Weight:
412.46
CAS Number:
[1430420-02-2]
Formula:
C24H16N2O3S
Target:
Apoptosis,Interleukin Related,STAT,TGF-beta/Smad
Application Notes:
MCE Product type: Reference compound1
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