ND-2110 is a selective IRAK4 inhibitor (Ki: 7.5 nM). ND-2110 binds to the ATP pocket of IRAK4. ND-2110 targets the subset of activated B cell-like (ABC) subtype of diffuse large B cell lymphoma (DLBCL) cell lines with MYD88 L265P mutations,. ND-2110 inhibits LPS-induced TNF production, alleviates collagen-induced arthritis, and blocks gout formation in mouse models[1].
Molecular Weight:
416.54
CAS Number:
[1388894-17-4]
Formula:
C21H28N4O3S
Target:
IRAK
Application Notes:
MCE Product type: Reference compound
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