VPC-14228 is an inhibitor that selectively targets androgen receptor DNA binding domain (AR-DBD). VPC-14228 inhibits the interaction between AR and DNA, thereby blocking AR-mediated transcriptional activation. VPC-14228 does not rely on nuclear localization inhibition, but rather inhibits the activity of full-length AR and splice variant AR-V7 by interfering with AR binding to chromatin. And VPC-14228 has high selectivity for other nuclear receptors such as ER and PR. VPC-14228 can be used in the study of prostate cancer[1][2].
Molecular Weight:
246.33
Purity:
99.36
CAS Number:
[19983-28-9]
Formula:
C13H14N2OS
Target:
Androgen Receptor
Application Notes:
MCE Product type: Reference compound
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