(R,R)-MK 287, CAS [[143490-81-7]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-117811
Supplier Catalog Number:
HY-117811
Alternative Catalog Number:
MCE-HY-117811-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Alternative Names:
L-680574
(R,R)-MK 287 (L-680574) is a tetrahydrofuran derivative that potently inhibits the binding of [3H]C18-PAF to human platelets, polymorphonuclear leukocytes (PMNs), and lung membranes with Ki values of 6.1, 3.2, and 5.49 nM, respectively. (R,R)-MK 287 potently and selectively inhibits PAF-induced platelet aggregation (ED50=56 nM) and elastase release from PMNs (ED50=4.4 nM). (R,R)-MK 287 inhibits PAF-induced lethality in mice (ED50=0.8 mg/kg, po) and PAF-induced bronchospasm in guinea pigs (ED50=0.18 mg/kg)[1].
Molecular Weight:
510.60
CAS Number:
[143490-81-7]
Formula:
C25H34O9S
Target:
Platelet-activating Factor Receptor (PAFR)
Application Notes:
MCE Product type: Reference compound
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