MRT-92 is a Smoothened (Smo) antagonist (Ki=0.7 nM) with anticancer activity. MRT-92 inhibits Hedgehog signaling pathway and rodent cerebellar granule cell proliferation by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor (IC50=0.4 nM). MRT-92 can be used in the study of cerebellar glioma[1].
Molecular Weight:
566.65
CAS Number:
[1428315-82-5]
Formula:
C33H34N4O5
Target:
Hedgehog,Smo
Application Notes:
MCE Product type: Reference compound
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