TRC210258 is a TGR5 agonist with activity to improve diabetes-associated hyperglycemia and dyslipidemia. TRC210258 promotes energy expenditure by enhancing the release of glucagon-like peptide-1. TRC210258 is able to improve glucose metabolic control in high-fat diet-induced obese mice. TRC210258 also showed improvement in lipid parameters in high-fat-fed hamsters, including reductions in plasma triglyceride and low-density lipoprotein cholesterol levels. TRC210258 improved emerging lipid-related cardiovascular risk parameters including remnant cholesterol and triglyceride clearance[1].
Molecular Weight:
396.80
Purity:
99.55
CAS Number:
[1431553-15-9]
Formula:
C20H14ClFN4O2
Target:
Endogenous Metabolite
Application Notes:
MCE Product type: Reference compound
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