ES-8891 is a renin inhibitor. Oral administration of ES-8891 to normotensive sodium-depleted macaques for one week significantly reduced plasma renin activity, immunoreactive renin concentrations, and plasma angiotensin I concentrations, while mean blood pressure decreased significantly, without significant changes in heart rate. ES-8891 regulates blood pressure by inhibiting plasma renin levels and renal renin synthesis[1].
Molecular Weight:
777.03
CAS Number:
[129445-88-1]
Formula:
C42H60N6O6S
Target:
Renin
Application Notes:
MCE Product type: Reference compound
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