GGTI-286 (hydrochloride), CAS [[181141-66-2]] Preis auf Anfrage

Product Overview

• Article Name: GGTI-286 (hydrochloride), CAS [[181141-66-2]] Preis auf Anfrage
• Biozol Catalog Number: MCE-HY-117935
• Supplier Catalog Number: HY-117935
• Alternative Catalog Number: MCE-HY-117935-1UNIT
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

GGTI-286 hydrochloride, a potent GGTase I inhibitor, is 25-fold more potent (IC50=2 µM) than the corresponding methyl ester of FTI-276 (HY-15873A). GGTI-286 hydrochloride selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC50s =2 and >30 µM, respectively). GGTI-286 hydrochloride also potently inhibits oncogenic K-Ras4B stimulation with an IC50 of 1 µM[1][2].

Product Properties

• Molecular Weight: 466.04
• CAS Number: [181141-66-2]
• Formula: C23H32ClN3O3S
• Target: Ras

Application Notes

• Application Notes: MCE Product type: Reference compound