T-3861174 is an orally active prolyl tRNA synthetase (a mediator of amino acid charging in protein synthesis) inhibitor with an IC50 of 2.3 nM. T-3861174 activates the GCN2-ATF4 pathway and induces death in multiple tumor cell lines. T-3861174 demonstrated significant antitumor activity in multiple xenograft models without significantly affecting body weight[1].
