L 743310 is a non-peptide, selective antagonist of the human neurokinin hNK1 receptor, with high affinity for primate and cloned human hNK1 receptors and lower affinity for rodent NK1 receptors. L 743310 inhibits resiniferatoxin-induced plasma protein extravasation in guinea pig esophagus. L 743310 has a dose-dependent inhibitory effect on cisplatin-induced emesis[1].
Molecular Weight:
675.50
CAS Number:
[187724-86-3]
Formula:
C30H33BrF6N4O2
Target:
Neurokinin Receptor
Application Notes:
Reference compound
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