Bozepinib is a PKR (RNA-dependent protein kinase) activator and potently inhibits the HER-2 signaling pathway as well as JNK and ERK kinases. Bozepinib induces PKR-mediated apoptosis and synergizes with IFNalpha to trigger apoptosis, autophagy and senescence. Bozepinib also demonstrates in vivo antitumor and antimetastatic efficacy in xenografted nude mice[1][2].
Molecular Weight:
521.33
CAS Number:
[1207993-83-6]
Formula:
C20H14Cl2N6O5S
Target:
Apoptosis,Autophagy,ERK,JNK
Application Notes:
MCE Product type: Reference compound
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