ABD459 is a CB1 receptor antagonist with significant effects on regulating food intake and sleep-wake cycles. ABD459 completely displaces CB1 agonist CP99540 (Ki = 8.6 nM) and antagonizes CP55940-induced GTPgammaS binding (KB = 7.7 nM). ABD459 may specifically modulate endogenous cannabinoid release through cholinergic activity and plays a role in attention and arousal regulation. ABD459 is suitable for research in neurological disorders[1].
Molecular Weight:
516.21
CAS Number:
[1047670-51-8]
Formula:
C24H17BrCl2N2O2
Target:
Cannabinoid Receptor
Application Notes:
MCE Product type: Reference compound
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