LS-104 (Tyrene CR-4) is a non-ATP-competitive kinase inhibitor against JAK2, Bcr-Abl and FLT3. LS-104 potently induces apoptosis in JAK2V617F-positive cells and inhibits JAK2 autophosphorylation and downstream signal transduction. LS-104 also inhibits proliferation and induces potent cytotoxic effects in FLT3 expressing leukemic cells. LS-104 is a hydroxystyryl-acrylonitrile compound, which is promising for research of myeloproliferative disorders and refractory/relapsed hematologic malignancies[1][2].
Molecular Weight:
320.34
CAS Number:
[368836-72-0]
Formula:
C19H16N2O3
Target:
Apoptosis,Bcr-Abl,FLT3,JAK
Application Notes:
MCE Product type: Reference compound
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