CAY10526 is a specific microsomal PGE2 synthase-1 (mPGES1) inhibitor. CAY10526 inhibits PGE2 production through the selective modulation of mPGES1 expression but does not affect COX-2. CAY10526 significantly suppresses tumor growth and increases apoptosis in melanoma xenografts. CAY10526 reduces BCL-2 and BCL-XL (anti-apoptotic) protein levels and increases BAX and BAK (pro-apoptotic) as well as cleaved caspase 3 levels. CAY10526 inhibits cell viability (IC50[1].
Molecular Weight:
311.16
Purity:
99.12
CAS Number:
[938069-71-7]
Formula:
C12H7BrO3S
Target:
PGE synthase
Application Notes:
MCE Product type: Reference compound
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