AF3485 is a human mPGES-1 inhibitor that exhibits antitumor activity in vitro and in vivo. AF3485 inhibits tumor-associated angiogenesis by reducing PGE2 production, inhibiting EGFR signaling, and decreasing VEGF and FGF-2 expression. AF3485 reduced tumor growth in mice bearing human A431 xenograft tumors by subchronic administration.
Molecular Weight:
398.38
CAS Number:
[1195786-61-8]
Formula:
C22H17F3N2O2
Target:
PGE synthase
Application Notes:
MCE Product type: Reference compound
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