FK960 is a potential anti-dementia agent that reverses the reduction in cerebral blood flow (rCBF) caused by sensory stimulation by enhancing cholinergic neurotransmission. In macaque experiments, physostigmine (AChE inhibitor, HY-N6608) was able to completely eliminate the rCBF in the sensory cortex increased by vibrotactile stimulation. FK960 (1-1000 µg/kg) can restore the eliminated rCBF response, and the action time can last for 1 hour. However, FK960 cannot restore the rCBF response eliminated by HA-966 (NMDA modulator, HY-100822), indicating that its function is not dependent on non-glutamatergic neurotransmission.
Molecular Weight:
265.28
CAS Number:
[133920-70-4]
Formula:
C13H16FN3O2
Target:
Cholinesterase (ChE)
Application Notes:
MCE Product type: Reference compound
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