mPGES-1-IN-2 (compound III) is a benzimidazole-based mPGES-1 inhibitor that also inhibits adipophysin PGD synthase (I-PGDS) (5 µM, IR=60 %). mPGES-1-IN-2 reduces PGE2 production and tends to reduce levels of other prostaglandins. mPGES-1-IN-2 effectively inhibits acute inflammation in an air sac model stimulated by Carrageenan (HY-125474) in mice[1].
Molecular Weight:
382.54
Purity:
99.78
CAS Number:
[1268709-57-4]
Formula:
C23H34N4O
Target:
PGE synthase
Application Notes:
MCE Product type: Reference compound
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