ADX71441 is an orally active, blood-brain barrier penetrant positive allosteric modulator of GABAB receptor. ADX71441 potentiates the activity of endogenous GABA at GABAB receptor, with an EC50 of 96 nM. ADX71441 functionally inhibits adenosine transporters and 5-HT2B receptor. ADX71441 produces anxiolytic-like, analgesic, muscle relaxant, hypothermic and overactive bladder inhibitory effects, reduces acute locomotor activity levels, decreases voluntary intake of alcohol and saccharin, attenuates stress-induced neuronal activation, and exhibits anti-hyperalgesic activity[1][2][3][4].
Molecular Weight:
436.80
Purity:
98.63
CAS Number:
[1207440-88-7]
Formula:
C19H15ClF2N4O4
Target:
5-HT Receptor,GABA Receptor
Application Notes:
MCE Product type: Reference compound
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