AKN-028, a novel tyrosine kinase (TK) inhibitor, is a potent, orally active FMS-like receptor tyrosine kinase 3 (FLT3) inhibitor with an IC50 value of 6 nM. AKN-028 inhibits FLT3 autophosphorylation. AKN-028 induces dose-dependent cytotoxic response (mean IC50=1 µM). AKN-028 induces apoptosisby activation of caspase 3. AKN-028 can be used in research of acute myeloid leukemia (AML)[1].
Molecular Weight:
302.33
CAS Number:
[1175017-90-9]
Formula:
C17H14N6
Target:
Apoptosis,Caspase,FLT3
Application Notes:
MCE Product type: Reference compound
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