GSK223 is a quinazolinone NOD1 pathway inhibitor with potential anti-inflammatory activity. GSK223 can selectively inhibit IL-8 release under iE-DAP stimulation without affecting IL-8 secretion caused by TNF receptor, TLR2 or NOD2 agonists. GSK223 does not directly inhibit RIP2 kinase activity.
Molecular Weight:
443.51
CAS Number:
[899758-61-3]
Formula:
C21H18FN3O3S2
Target:
NOD-like Receptor (NLR)
Application Notes:
MCE Product type: Reference compound
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