WRR-483 is an analog of K11777, an inhibitor of cruzain, used to inhibit the proliferation of Trypanosoma cruzi in cell culture. WRR-483 can eradicate parasitic infection in an acute Chagas disease mouse model. WRR-483 is an irreversible cysteine protease inhibitor that shows pH-dependent high affinity and potent trypanocidal activity against cruzain and T. cruzi infection, and is expected to inhibit Chagas disease.
Molecular Weight:
583.75
CAS Number:
[1076088-50-0]
Formula:
C29H41N7O4S
Target:
Parasite
Application Notes:
MCE Product type: Reference compound
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