ER-67880 is a potent microtubule inhibitor with an IC50 of 9.5 µM. ER-67880 exhibits anti-proliferative activity against KB, Colon 38 and P338 cells with IC50s of 0.55, 0.2 and 0.76 µg/mL. ER-67880 causes G2/M phase arrest and is accompanied by abnormal DNA replication. ER-67880 exhibits a down-regulation pattern of G1 phase-related genes. ER-67880 can be used in various cancer studies, including those of nasopharyngeal carcinoma and murine adenocarcinoma[1][2].
Molecular Weight:
336.79
CAS Number:
[247186-96-5]
Formula:
C15H13ClN2O3S
Target:
Microtubule/Tubulin
Application Notes:
MCE Product type: Reference compound
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