TP-110 is a proteasome inhibitor. TP-110 specifically inhibits the protease-like activity of the 20S proteasome, but does not affect the trypsin-like or peptidyl-glutamyl peptide hydrolysis activity. TP-110 inhibits the NF-kappaB pathway, activates caspase-8, -9, and -3, and causes PARP cleavage, significantly reducing the levels of cIAP-1 and XIAP. TP-110 causes cell cycle arrest at the G2/M phase and promotes apoptosis of cancer cells. TP-110 can be used in cancer research of prostate cancer and multiple myeloma, etc[1][2].
Molecular Weight:
623.74
CAS Number:
[688737-95-3]
Formula:
C37H41N3O6
Target:
Apoptosis,Caspase,IAP,NF-kappaB,PARP,Proteasome
Application Notes:
MCE Product type: Reference compound
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