NS-6740 (hydrochloride), CAS [[753499-14-8]] Preis auf Anfrage

Product Overview

• Article Name: NS-6740 (hydrochloride), CAS [[753499-14-8]] Preis auf Anfrage
• Biozol Catalog Number: MCE-HY-118646A
• Supplier Catalog Number: HY-118646A
• Alternative Catalog Number: MCE-HY-118646A-1UNIT
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

NS-6740 hydrochloride is a partial agonist of alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) with an IC50 of 3 nM. NS-6740 hydrochloride also acts as a potent modulator of the cholinergic anti-inflammatory pathway. NS-6740 hydrochloride alters the signaling pattern of alpha7 in an ion channel-independent manner, thereby reducing synaptic function. NS-6740 hydrochloride induces the desensitized state of alpha7 nAChR. NS-6740 hydrochloride generates robust nAChR-mediated currents. NS-6740 hydrochloride reduces LPS (HY-D1056)-induced TNF-alpha release from microglia. NS-6740 hydrochloride can be used in the research of neuroinflammation and neuropathic pain[1][2].

Product Properties

• Molecular Weight: 400.82
• CAS Number: [753499-14-8]
• Formula: C19H20ClF3N2O2
• Target: nAChR,TNF Receptor

Application Notes

• Application Notes: MCE Product type: Reference compound