L-736380 is a high affinity CCK-B (cholecystokinin B receptor) receptor antagonist, with IC50 values of 0.054 nM and 400 nM for CCK-B and CCK-A, respectively. L-736380 dose-dependently inhibits gastric acid secretion in anesthetized rats (ID50, 0.064 mg/kg) and ex vivo binding of [125I]CCK-8S in BKTO mice brain membranes (ED50, 1.7 mg/kg)[1].
Molecular Weight:
487.56
CAS Number:
[152885-49-9]
Formula:
C25H29N9O2
Target:
Cholecystokinin Receptor
Application Notes:
MCE Product type: Reference compound
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