BMH-22, a benzonaphthyridin, is a RNA polymerase I (Pol I) transcription inhibitor independent of p53 function. BMH-22 causes reorganization of nucleolar marker proteins consistent with segregation of the nucleolus. BMH-22 destabilizes RPA194 in a proteasome-dependent manner and inhibits nascent rRNA synthesis and expression of the 45S rRNA precursor. BMH-22 shows potent anticancer activity across many tumor types[1].
Molecular Weight:
251.33
Purity:
98.85
CAS Number:
[309726-06-5]
Formula:
C16H17N3
Target:
DNA/RNA Synthesis
Application Notes:
MCE Product type: Reference compound
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