JTC-017, a specific corticotropin-releasing hormone receptor 1 antagonist, attenuates hippocampal noradrenaline release, visceral perception, adrenocorticotropic hormone release, and anxiety after acute colorectal distention in rats. JTC-017 blocks stress-induced changes in colonic motility after chronic colorectal distention in rats[1].
Molecular Weight:
490.40
CAS Number:
[357330-77-9]
Formula:
C20H25Cl2N3O5S
Target:
CRFR
Application Notes:
MCE Product type: Reference compound1
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