VX-148 is an orally active immunosuppressant, which is a non-competitive inosine-5-monophosphate dehydrogenase (IMPDH) inhibitor with Ki values for IMPDH II and IMPDH 1 of 6 and 14 nM respectively. VX-148 can significantly inhibit the proliferation of human peripheral blood mononuclear cells (PBMC) stimulated by T-cell mitogen (PHA) or B-cell mitogen (SPAS). VX-148 has high selectivity for lymphocytes (such as L1210, Jurkat T cells, and Raji B cells), but has no significant toxicity to non-lymphoid cells. VX-148 can inhibit antibody responses in mouse models and significantly prolong the survival time of transplanted skin in allogeneic skin transplantation models. VX-148 can be used in the research of autoimmune diseases (such as rheumatoid arthritis, psoriasis) and organ transplantation anti-rejection[1][2].
Molecular Weight:
435.48
CAS Number:
[297730-05-3]
Formula:
C23H25N5O4
Target:
IMPDH
Application Notes:
MCE Product type: Reference compound
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