CRX-526 is a TLR4 antagonist that can block the interaction of lipopolysaccharide (LPS, HY-D1056) with the immune system, including preventing the expression of pro-inflammatory genes stimulated by LPS, as well as blocking the release of TNF-alpha induced by LPS. CRX-526 exhibits anti-inflammatory effects in two mouse models of colitis (namely, the dextran sodium sulfate-induced colitis model and the multidrug resistance gene 1a-deficient mouse model)[1].
Molecular Weight:
1319.72
CAS Number:
[245515-64-4]
Formula:
C69H127N2O19P
Target:
Toll-like Receptor (TLR)
Application Notes:
MCE Product type: Reference compound
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