TX2-121-1 is a potent and selective Her3 (ErbB3) degrader that contains a hydrophobic adamantane moiety. TX2-121-1 has an IC50 of 49 nM for Her3. TX2-121-1 inhibits Her3-dependent signaling and heterodimerization of Her3. TX2-121-1 has the ability to inhibit cell proliferation. TX2-121-1 can be used in the study of tumors. (Pink: Her3 inhibitor (HY-164988), Black: Linker, Blue: Adamantane (HY-N2427))[1].
Molecular Weight:
716.91
CAS Number:
[1603845-42-6]
Formula:
C42H52N8O3
Target:
Akt,EGFR,ERK,PROTACs
Application Notes:
MCE Product type: Reference compound
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