SK1-I (BML-258), an analog of sphingosine, is an isozyme-specific competitive SPHK1 inhibitor with a Ki value of 10 µM[1]. SK1-I shows no activity at SPHK1 PKCalpha, PKCdelta, PKA, AKT1, ERK1, EGFR, CDK2, IKKbeta or CamK2beta. SK1-I enhances autophagy and has antitumor activity[2].
Molecular Weight:
277.40
Purity:
98.83
CAS Number:
[1072443-89-0]
Formula:
C17H27NO2
Target:
CaMK,SphK
Application Notes:
MCE Product type: Reference compound
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