R-75317 is a specific platelet-activating factor (PAF) antagonist. R-75317 can prevent the decline in creatinine clearance (Ccr) in a rat model of glomerulonephritis induced by the injection of antibodies extracted from rabbits against rat glomerular basement membrane (GBM) antigens, delay the onset of proteinuria, and improve glomerular hypertrophy, mesangial matrix proliferation, and interstitial fibrosis. R-75317 may be useful in the study of glomerulonephritis[1].
Molecular Weight:
631.76
CAS Number:
[115406-25-2]
Formula:
C29H50N3O8PS
Target:
Platelet-activating Factor Receptor (PAFR)
Application Notes:
MCE Product type: Reference compound
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