A-800141 is an orally active and selective MetAP2 inhibitor with an IC50 of 12 nM. A-800141 has weak inhibitory activity for MetAP1 (IC50 : 36 µM). GAPDH can be used as a biomarker to monitor the MetAP2 inhibition of A-800141. A-800141 has antiangiogenic and anticancer activity in a variety of xenograft tumor models[1].
Molecular Weight:
442.57
CAS Number:
[681245-85-2]
Formula:
C24H30N2O4S
Target:
MetAP
Application Notes:
MCE Product type: Reference compound
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