AS1604498 is a highly specific competitive inhibitor of human NAMPT, with an IC50 of 44.4 nM. AS1604498 functionally inhibits NAMPT enzymatic activity, reduces nicotinamide mononucleotide production, decreases intracellular NAD levels, activates caspase 3/7 and induces cancer cell apoptosis. AS1604498 is applicable to research related to chronic myeloid leukemia[1].
Molecular Weight:
319.36
CAS Number:
[361465-74-9]
Formula:
C19H17N3O2
Target:
Apoptosis,Caspase,NAMPT
Application Notes:
MCE Product type: Reference compound
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