AZ084 is a potent, selective, allosteric and oral active CCR8 allosteric antagonist, with a Ki of 0.9 nM. Has potential to treat asthma[1]. AZ084 restrains the formation of the immunologically tolerant pre-metastatic niche (PMN) and tumor cells metastasis in lung by downregulating Treg differentiation. AZ084 can be used in studies of asthma and cancer[1][2].
Molecular Weight:
434.57
Purity:
99.65
CAS Number:
[929300-19-6]
Formula:
C26H34N4O2
Target:
CCR
Application Notes:
MCE Product type: Reference compound
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