AW-814141 is a selective and orally active p38 MAP kinase inhibitor. AW-814141 has an IC50 values of 100 nM and 158 nM for p38-alpha and beta isoforms, respectively. AW-814141 can inhibit the production of TNF-alpha induced by LPS (HY-D1056). AW-814141 can inhibit paw edema in rats in a dose-dependent manner. AW-814141 exhibits anti-inflammatory activity and can be used in the research of inflammatory diseases such as rheumatoid arthritis[1].
Molecular Weight:
375.47
CAS Number:
[905285-51-0]
Formula:
C22H25N5O
Target:
p38 MAPK
Application Notes:
MCE Product type: Reference compound
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