CM-414 is a brain-penetrant phosphodiesterase 5 (PDE5) and HDAC inhibitor with IC50s of 60 nM, 91 nM, 310 nM, 322 nM and 490 nM for PDE5, HDAC6, HDAC1, HDAC3 and HDAC2, respectively. CM-414 diminishes brain Abeta and tau phosphorylation (pTau) level in Tg2576 mice. CM-414 can be used for the study of Alzheimers disease (AD)[1][2].
Molecular Weight:
439.52
CAS Number:
[2007971-51-7]
Formula:
C23H29N5O4
Target:
Amyloid-beta,HDAC,Phosphodiesterase (PDE),Tau Protein
Application Notes:
MCE Product type: Reference compound
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