CE-2072 is an inhibitor of serine proteases neutrophil elastase and proteinase-3. CE-2072 inhibits HIV-1 production and p24 production in response to IL-18 or NaCl in infected U1 monocytic cells, reduces virus replication in infected peripheral blood mononuclear cells and blocks infection of permissive HeLa cells. CE-2072 suppresses activation of the HIV-1-inducing transcription factor NF-kB in U1 cells. CE-2072 is promising for research of HIV-1-related disease[1].
Molecular Weight:
603.71
CAS Number:
[208840-22-6]
Formula:
C33H41N5O6
Target:
Ser/Thr Protease
Application Notes:
MCE Product type: Reference compound
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