MS37452 is a potent inhibitor of CBX7 chromodomain binding to H3K27me3, with a Kd of 27.7 µM. MS37452 can derepress transcription of polycomb repressive complex target gene p16/CDKN2A by displacing CBX7 binding to the INK4A/ARF locus in prostate cancer cells[1].
Molecular Weight:
398.45
Purity:
99.81
CAS Number:
[423748-02-1]
Formula:
C22H26N2O5
Target:
Histone Methyltransferase
Application Notes:
MCE Product type: Reference compound
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