Simvastatin acid (Tenivastatin), a hydrolysate of Simvastatin (HY-17502), is a HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1][2].
Molecular Weight:
436.58
Purity:
99.66
CAS Number:
[121009-77-6]
Formula:
C25H40O6
Target:
HMG-CoA Reductase (HMGCR),Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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