Simvastatin acid-d6 (ammonium)mis the deuterium labeled Simvastatin acid ammonium. Simvastatin ammonium is an active metabolite of simvastatin lactone mediated by CYP3A4/5 in the intestinal wall and liver (pKa=5.5). Simvastatin ammonium reduces indoxyl sulfate-mediated reactive oxygen species and modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1].
Molecular Weight:
459.65
Formula:
C25H37D6NO6
Target:
Endogenous Metabolite,Isotope-Labeled Compounds
Application Notes:
MCE Product type: Isotope-Labeled Compounds
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