UK-500001 is an orally active inhibitor for phosphodiesterase 4 (PDE4), which inhibits PDE4D3 (IC50 is 0.28 nM), PDE4B2 (IC50 is 22.8 nM), PDE4A4 (IC50 is 26.1 nM) and PDE4C2 (IC50 is 271 nM). UK-500001 exhibits anti-inflammatory efficacy and inhibits TNF-alpha and IFN-gamma release in human and rodent macrophagic cell lines in nanomolar levels. UK-500001 ameliorates chronic obstructive pulmonary disease (COPD) and asthma[1].
Molecular Weight:
499.48
CAS Number:
[582332-31-8]
Formula:
C26H24F3N3O4
Target:
Phosphodiesterase (PDE)
Application Notes:
MCE Product type: Reference compound
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