Rubone, a chalcone analog, is a modulator of miR-34a. Rubone upregulates miR-34a expression in a p53 dependent manner, downregulates the downstream target Bcl-2 and Cyclin D1 expression, and suppresses hepatocellular carcinoma (HCC) growth in vivo. Rubone enhances the anticancer effect of Paclitaxel (PTX, HY-B0015) in PTX-resistant prostate cancer cell lines by reversing the expression of miR-34a downstream targets[1][2][3].
Molecular Weight:
374.38
Purity:
99.1
CAS Number:
[73694-15-2]
Formula:
C20H22O7
Target:
MicroRNA
Application Notes:
MCE Product type: Reference compound
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