Asterric acid is an antibiotic fungal metabolite that completely inhibits the binding of the potent vasoconstrictor endothelin (ET)-1 to the ETA receptor in A10 cells at 0.1 µM.1 Asterric acid derivatives have also been shown to inhibit VEGF-induced tube formation of human umbilical vein endothelial cells at 3-10 µM, which suggests its usefulness as an antiangiogenic agent.
Molecular Weight:
348.30
CAS Number:
[577-64-0]
Formula:
C17H16O8
Target:
Antibiotic
Application Notes:
MCE Product type: Reference compound
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