AKCI is a type of AURKC-IkappaBalpha interaction inhibitor, with an IC50 value of 24.9 µM. In MDA-MB-231 cells, AKCI can induce G2/M cell cycle arrest by regulating the p53/p21/CDC2/cyclin B1 pathway, inhibit cell migration and invasion, and reduce colony formation and tumor growth. AKCI can be used for research on breast cancer[1].
Molecular Weight:
369.46
CAS Number:
[669750-88-3]
Formula:
C19H27N7O
Target:
Cyclin G-associated Kinase (GAK),MDM-2/p53
Application Notes:
MCE Product type: Reference compound1
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