Fluphenazine is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine blocks neuronal voltage-gated sodium channels. Fluphenazine acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2[1][2][3][4][6].
Molecular Weight:
437.52
Purity:
98.70
CAS Number:
[69-23-8]
Formula:
C22H26F3N3OS
Target:
Dopamine Receptor,SARS-CoV,Sodium Channel
Application Notes:
MCE Product type: Reference compound
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