KB130015 (KB015) is an orally active and potent ThRalpha and ThRbeta (thyroid hormone receptor) inhibitor, with IC50 values of 4.5 and 5.1 µM, respectively. KB130015 markedly slows the kinetics of inactivation of Na+ channels. KB130015 activates hERG1 channels (EC50 = 12.2 µM) and large-conductance Ca2+-activated K+ (BKCa) channels formed by hSlo1 (alpha) subunits in HEK 293 cells. KB130015 has antiarrhythmic properties. KB130015 can be used for the study of cardiovascular disease[1][2][3][4].
