YM116 is an orally active and competitive CYP17A1 (17,20-lyase) inhibitor (Ki: 0.38 nM). YM116 reduces the synthesis of adrenal androgens by preferentially inhibiting C17-20 lyase activity. YM116 decreases the serum testosterone concentration, reduces dehydroepiandrosterone sulfate levels and decreases prostatic weights[1][2].
Molecular Weight:
247.29
CAS Number:
[183012-13-7]
Formula:
C16H13N3
Target:
Cytochrome P450
Application Notes:
MCE Product type: Reference compound1
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